This study was carried out to assess secondary school teachers’ perception towards using learning management system in Oyo State. The survey research design was used. The population for this study consisted of 15, 705 registered teachers. The sample of the study were 1,400 respondents. Multi-stage sampling procedure was used to select the sample. The instrument for data collection was an adapted questionnaire from Olorunmonu (2024). The instrument was validated and tested for reliability using Cronbach’s alpha which yielded 0.85. Mean, percentage, ANOVA, t-test, Pearson Product Moment Correlation, (PPMC) were used to answer research questions and test hypotheses at 0.05 level of significance respectively. The results of the findings indicated that teachers have positive perceptions towards the use of LMS with (2.95); there were no significant difference in teachers’ perception of LMS use based on educational qualification and gender; there was significant difference in teachers’ perception of LMS use based on work experience; (t=4.631, P=0.003 P ˂ 0.05); and there was significant relationship of institutional support and teachers’ perception of LMS use; (t=0.142, P= .001   P ˂ 0.05;) . It was recommended that secondary school teachers in Oyo State be encouraged to undergo courses on making use of LMS to enhance efficient teaching and effective learning.