The study investigates the mindfulness and emotional intelligence as mediating factors of psychological security among university students in Nigeria. The study was guided with three research questions and hypotheses. The study adopted a descriptive research design of correlation type. A total of 306 University students were selected using purposive sampling technique. Three instruments were administered on mindfulness and emotional intelligence and psychological security, which were validated by two experts. The reliability of the instruments is SMQ, EIQ and SPSQ has 0.72, 0.78 and 0.69 respectively. Multiple Regression Analysis and Pearson Product Moment Statistic were used to test the hypotheses at 0.05 level of significance. The findings showed that the level of the mindfulness, emotional intelligence and psychological security were high among University students. All independent variables jointly accounted for 63.6% variance in predicting psychological security among University students in Katsina state. Also, mindfulness (β = .771; p<0.05) and emotional intelligence (β = .169; p<0.05) had relative contributions to psychological security. Also, the findings showed that mindfulness (r = .781; p<0.05) and emotional intelligence (r = .781; p<0.05) had significant relationship to psychological security among University students in Katsina state. The study recommended that there is need to improve students’ awareness (mindfulness) and emotional stability that can help with communication channels and strategic alignment in psychological security.